After taking a cheap shot at Marvel's distinguished competition by way of the bat-signal, Dan Slott pits Doctor Octopus -now in Spider-Man's body- against one of his fellow villains, the Vulture. Looking at his former Sinister-Six ally through new eyes, Octavius understands a little bit better why Spider-Man did the things he did; however, this is not by any means stopping him from delivering his rough brand of justice after their confrontation goes awry.

While this is happening, Peter Parker, who is lost inside Octopus' consciousness, starts a discovery journey of his own. Thus far, readers had seen the bad guy accessing the memories of the good one; now, it is the other way around, and Peter will begin to understand his arch-enemy's tragic life and motivations. Another huge development takes place in the form of officer Carlie Cooper and her realization that something is definitely off with the web-crawler; her road to find the truth is about to get very rocky. Overall, the issue is not bad at all.