The Astonishing X-Men gather to help Wolverine and rescue the missing Karma after a gruesome encounter that took place during Northstar's wedding celebration. The focus of the story is Cecilia Reyes, a somewhat obscure but well-liked former X-Man who recently rejoined the fray. Her preference to practice medicine over a life of adventure has always been a distinctive quality of this character, and one that makes her very appealing.

What Liu does in this issue is play with the idea that despite her reluctance, deep inside Cecilia likes being part of the X-Men's heroics. Her flirting relationship with Beast also goes a long way back, and is brought to the forefront once again; this has potential for interesting dynamics with Agent Brand -Beast's current love interest. This issue establishes a good the balance between characterization and action, but the artwork finishes are somewhat lackluster.